TEM

Tempus AI

$67.76

+1.51%
Oct 21, 2026
Bobby Quantitative Model
Tempus AI, Inc. operates a technology platform that frees healthcare data from silos and applies artificial intelligence, including generative AI, to make laboratory diagnostics more accurate, tailored, and personal, competing in the medical healthcare information services and precision medicine industry. The company is positioned as a data-and-AI platform player rather than a traditional diagnostics lab, monetizing both Intelligent Diagnostics testing volume and its multimodal real-world data library through partnerships with pharma and health systems. The current investor narrative centers on the pending Personalis acquisition, which bulls argue could transform Tempus's precision medicine franchise and deepen its genomic data moat, a thesis that drove a sharp August rally. Against that optimism sits a persistent debate over cash burn, heavy stock-based compensation, and whether the company's roughly 21.6% revenue growth can scale into durable profitability, leaving the stock a high-conviction battleground between AI-healthcare believers and skeptics of its valuation.

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TEM 12-Month Price Forecast

Historical Price
Current Price $67.76
Average Target $67.76
High Target $77.92
Low Target $57.60

Wall Street consensus

Most Wall Street analysts maintain a constructive view on Tempus AI's 12-month outlook, with a consensus price target around $74.94 and implied upside of +10.6% versus the current price.

Average Target

$74.94

0 analysts

Implied Upside

+10.6%

vs. current price

Analyst Count

—

covering this stock

Price Range

$35 - $100

Analyst target range

Coverage is robust, with 18 analysts and a consensus recommendation of buy (mean rating 2.2 on a scale where lower is more bullish). The average target price of $74.94 implies roughly 15.8% upside from the current $64.72, a moderately bullish stance that has not been fully validated by price action given the stock's 9.01% single-day drop. Recent institutional actions lean constructive, including Piper Sandler's upgrade to Overweight from Neutral on September 1, 2026, alongside reiterated Buy ratings from HC Wainwright, BTIG, and Needham, though Stifel and Freedom Capital Markets remain at Hold.

The target range of $35.00 to $100.00 is extremely wide, spanning roughly 2.9x from low to high, which signals high uncertainty rather than strong conviction. The $100 high target likely assumes successful integration of the Personalis acquisition, accelerating data-services revenue, and multiple expansion toward the upper end of its historical PS band, while the $35 low target prices in margin compression, continued cash burn, and dilution that erodes the equity story. The dispersion, combined with a beta of 3.54 and a short ratio of 3.69, means analyst sentiment is directionally positive but the outcome distribution is fat-tailed, and investors should treat the consensus target as a central tendency rather than a reliable price objective.

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Bulls vs Bears: TEM Investment Factors

The bear case currently has stronger near-term evidence: operating margins are -19.85%, TTM FCF is -$272.97 million, stock comp runs $54 million a quarter, and the stock just fell 9.01% in a session with negative one-month relative strength of -8.72 points. The bull case rests on valuation compression (8.09x PS versus 27-52x historically), improving gross margin (64.45%), a buy consensus with 15.8% upside, and the Personalis catalyst. The single most important tension is whether 21.56% revenue growth can convert into operating leverage before the $604.34 million cash pile and investor patience run out; resolution of that question, more than any multiple, determines the thesis.

Bullish

  • PS multiple near post-IPO lows: At 8.09x trailing sales, TEM trades far below its own historical PS band of 27-28x in 2025-2026 and 42-52x in 2024. The compression reflects revenue scaling plus a 28.89% one-year decline, meaning the market now embeds far more modest expectations than at any prior point.
  • Gross margin steadily expanding: Gross margin rose from 60.69% in Q1 2025 to 64.45% in Q2 2026, with gross profit of $246.5 million on $382.5 million of revenue. That 380bp improvement shows the diagnostics-plus-data mix is gaining operating leverage at the unit level even while total opex remains heavy.
  • Analyst consensus buy with upside: 18 analysts carry a mean rating of 2.2 (buy) and an average target of $74.94, implying roughly 15.8% upside from $64.72. Piper Sandler upgraded to Overweight on September 1, 2026, alongside reiterated Buys from HC Wainwright, BTIG, and Needham.
  • Personalis deal as re-rating catalyst: The August rally from $49.36 on August 18 to $72.69 on August 21 was driven by validation of the pending Personalis acquisition, which bulls argue deepens the genomic data moat. A successful close and integration could expand the precision medicine franchise and data-services monetization.

Bearish

  • Persistent cash burn and negative FCF: TTM free cash flow is -$272.97 million, with Q2 operating cash flow of -$7.53 million following -$83.34 million in Q1. The company funds growth from its cash pile and external financing rather than internal generation, a structural vulnerability if capital markets tighten.
  • Operating losses remain deeply negative: Q2 2026 operating income was -$75.91 million (-19.85% margin) on $322.41 million of opex, including $96.57 million of R&D. The headline $5.64 million net profit was flattered by $81.86 million of other income, so the underlying loss trajectory is the truer signal.
  • Heavy dilution from stock compensation: Stock-based compensation was $54.12 million in Q2 alone, and diluted shares rose from 173.4 million in Q2 2025 to 182.4 million in Q2 2026. This dilutes per-share economics and undermines cash-flow quality even as revenue grows.
  • Extreme volatility and drawdown risk: Beta of 3.54 and a 59.76% maximum drawdown mean the stock can lose a third of its value in weeks. The 9.01% single-session drop to $64.72 on 6.86 million shares signals distribution, and one-month relative strength is -8.72 points versus SPY.

TEM Technical Analysis

Tempus AI is in a volatile, range-bound recovery rather than a clean uptrend: the stock is down 28.89% over the past year but up 3.78% year-to-date, and at $64.72 it sits at roughly 43% of its 52-week range of $40.77 to $96.29. That mid-range positioning reflects a market that has neither fully rejected nor re-embraced the story, and the 59.76% maximum drawdown underscores how punishing the downside has been for momentum holders. The stock is trading about 33% below its 52-week high but roughly 59% above its 52-week low, a wide band that argues for disciplined entry rather than chasing strength.

Short-term momentum has deteriorated sharply and diverges from the improving three-month trend: the stock fell 7.50% over the past month and 9.01% in the single session to $64.72 from $71.13, even as it gained 23.35% over three months and 15.84% over six months. That divergence signals a mean-reversion pullback within a recovering intermediate trend rather than a confirmed reversal, but the velocity of the drop is a warning. Relative strength tells the same story: -8.72 points versus SPY over one month and -44.42 over one year, yet +20.66 over three months, meaning the stock has recently been a strong outperformer that is now ceding ground. Volume of roughly 6.86 million shares on the down day suggests distribution rather than quiet profit-taking.

Key technical levels are well defined: support sits at the $40.77 52-week low, with intermediate support near the $61-62 area that held in early September, while resistance is anchored at the $96.29 52-week high and the $85 region where the September rally stalled. A breakout above $85-96 would signal the market is re-rating the Personalis-driven growth story, whereas a breakdown below $61 would put the $40.77 low back in play and confirm the one-month downtrend. With a beta of 3.54, the stock is roughly 3.5 times as volatile as the S&P 500, so position sizing must account for swings that can erase a third of value in weeks, as the 59.76% max drawdown demonstrates.

Beta

3.54

3.54x market volatility

Max Drawdown

-59.8%

Largest decline past year

52-Week Range

$41-$93

Price range past year

Annual Return

-24.0%

Cumulative gain past year

PeriodTEM ReturnS&P 500
1m-13.2%-0.1%
3m+47.3%+4.7%
6m+30.0%+8.3%
1y-24.0%+15.2%
ytd+8.7%+13.4%

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TEM Fundamental Analysis

Revenue is growing at a solid but decelerating-looking pace: Q2 2026 revenue of $382.49 million rose 21.56% year-over-year versus $314.64 million in Q2 2025, and the sequential path from $334.21 million in Q3 2025 to $348.12 million in Q1 2026 to $382.49 million in Q2 2026 shows steady expansion. Diagnostics contributed $289.33 million of segment revenue, the dominant driver of the top line, while the remainder comes from data and services. The trajectory supports the growth thesis, but the 21.56% YoY rate is more moderate than the hyper-growth multiple the stock commands, making execution on the Personalis acquisition and data monetization critical to justifying further re-rating.

Profitability is thin and inconsistent: Q2 2026 net income was just $5.64 million on a 1.48% net margin, a sharp swing from a $125.92 million loss in Q1 2026 and a $54.17 million loss in Q4 2025, and operating income remained negative at -$75.91 million (-19.85% operating margin). Gross margin has been stable and improving, from 60.69% in Q1 2025 to 64.45% in Q2 2026, which is respectable for a diagnostics-and-data hybrid but not enough to offset $322.41 million in quarterly operating expenses, including $96.57 million of R&D. The Q2 profit appears flattered by $81.86 million of other income, so the underlying operating loss trajectory, not the headline EPS of $0.03, is the truer signal.

Balance sheet liquidity is a strength but cash generation is not: the current ratio is 3.13 and cash stood at $604.34 million at Q2 2026, yet free cash flow TTM is -$272.97 million and Q2 operating cash flow was -$7.53 million after a -$83.34 million Q1. Debt-to-equity of 2.70 and a debt ratio of 0.61 reflect the convertible-heavy capital structure, while ROE of -49.87% and ROA of -8.83% confirm capital is being consumed rather than compounded. Stock-based compensation of $54.12 million in Q2 alone is a meaningful dilution and cash-flow quality issue, meaning the company still depends on its cash pile and external financing rather than internal cash generation to fund growth.

Quarterly Revenue

$382486000.0B

2026-06

Revenue YoY Growth

+21.6%

YoY Comparison

Gross Margin

64.5%

Latest Quarter

Free Cash Flow

$-272973000.0B

Last 12 Months

Revenue & Net Income Trends (2 Years)

Revenue Breakdown

Diagnostics

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Valuation Analysis: Is TEM Overvalued?

Because trailing net income is negative (EPS of -$0.02 and a trailing PE of -41.88), the PE ratio is not meaningful, so the PS ratio is the appropriate primary metric, and at 8.09x sales it is the cleanest read on how the market prices Tempus's revenue base. The forward PE of -1,373.81 is distorted by near-zero estimated earnings, while the PEG ratio of 0.60 and EV/Sales of 9.40 frame a stock priced for substantial future growth. The gap between the 8.09x trailing PS and the 9.40x EV/Sales reflects the net debt and convertible load embedded in enterprise value.

Against the healthcare information services sector, an 8.09x PS and 9.40x EV/Sales represent a clear premium to typical industry multiples, though the provided valuation data does not include a direct industry average, so the spread cannot be precisely quantified. The premium is defensible only if Tempus sustains above-market growth and converts its 64.45% gross margin into operating leverage; the -19.88% operating margin and -19.27% net margin show that conversion has not yet happened. A price-to-book of 20.94x further signals that investors are paying for intangible data assets and future earnings rather than current book value.

Historically, Tempus's PS ratio has compressed dramatically from 27.25x in Q2 2026 and 28.02x in Q4 2025 to 8.09x today, and from far higher levels of 42-52x in 2024, placing the current multiple near the low end of its own post-IPO band. That compression reflects both the revenue base scaling up and the stock's 28.89% one-year decline, which can be read either as a value opportunity if growth holds or as the market repricing a formerly speculative name. With the stock at 43% of its 52-week range and PS near historical lows, the valuation now embeds more modest expectations than at any prior point, raising the bar for downside surprise but also the payoff if the Personalis thesis delivers.

PE

-41.9x

Latest Quarter

vs. Historical

N/A

5-Year PE Range 17x~59x

vs. Industry Avg

N/A

Industry PE ~N/A*

EV/EBITDA

-92.9x

Enterprise Value Multiple

Investment Risk Disclosure

Financial and operational risks are acute. TTM free cash flow is -$272.97 million and Q2 operating income was -$75.91 million on a -19.85% margin, meaning the company consumes capital at scale. Debt-to-equity of 2.70 and a debt ratio of 0.61 reflect a convertible-heavy structure with $10.28 million of quarterly interest expense, while ROE of -49.87% and ROA of -8.83% confirm capital destruction. Stock-based compensation of $54.12 million in Q2 alone accelerates dilution, with diluted shares up from 173.4 million to 182.4 million year-over-year.

Market and competitive risks center on valuation and volatility. At 8.09x PS and 9.40x EV/Sales, TEM still commands a premium to typical healthcare information services multiples, defensible only if above-market growth persists. Beta of 3.54 means the stock amplifies market moves roughly 3.5x, and the June 2026 rotation out of high-flying tech into defensives (per Benzinga) illustrates how sector rotation can punish this name regardless of fundamentals. Competition in AI-driven precision medicine and data monetization is intensifying, and the Personalis integration adds execution risk to an already complex platform story.

Worst-case scenario: the Personalis deal closes but integration costs spike, data-services revenue disappoints, and a quarterly miss triggers downgrades, compressing the multiple further while cash burn forces dilutive financing. The 52-week low of $40.77 represents roughly -37% from $64.72, and the analyst low target of $35 implies about -46%. Given the 59.76% max drawdown already realized, an investor could realistically lose 35-46% from current levels in an adverse scenario, with the $61-62 intermediate support the first line of defense.