Summit Therapeutics
SMMT
$13.66
-8.81%
Summit Therapeutics is a biopharmaceutical company focused on discovering, developing, and commercializing novel antibiotics for serious infectious diseases, with its lead candidate ridinilazole targeting Clostridioides difficile infection. As a pre-revenue biotechnology firm, it operates in a niche but critical area of antimicrobial resistance, distinguishing itself through a pipeline centered on a potentially first-in-class oral antibiotic. The current investor narrative revolves around the company's cash runway, clinical trial progress, and the recent shift in analyst sentiment following a downgrade from Jefferies, amid broader market rotation away from speculative biotech names.…
SMMT
Summit Therapeutics
$13.66
SMMT 12-Month Price Forecast
Wall Street consensus
Most Wall Street analysts maintain a constructive view on Summit Therapeutics's 12-month outlook, with a consensus price target around $28.68 and implied upside of +110.0% versus the current price.
Average Target
$28.68
0 analysts
Implied Upside
+110.0%
vs. current price
Analyst Count
—
covering this stock
Price Range
$10 - $45
Analyst target range
Six analysts cover Summit Therapeutics, with a consensus leaning bullish: recent ratings include 4 Buys (HC Wainwright, Guggenheim, Citigroup, JMP Securities), 1 Hold (Jefferies downgraded from Buy), and 1 Equal Weight (Barclays upgraded from Underweight). The average target price is not directly provided, but based on estimated EPS of $1.72 and a forward PE of -13.18, the implied price is around $22.66 (EPS * PE), suggesting upside from the current $15.42. However, given negative earnings, this is unreliable. The high target from estimated EPS high of $2.12 implies a price of $27.94, while the low target of $1.32 implies $17.40. The wide spread (from $17.40 to $27.94) indicates high uncertainty. The recent downgrade by Jefferies to Hold from Buy on March 16, 2026, and the upgrade by Barclays from Underweight to Equal Weight on December 17, 2025, show shifting sentiment. The bullish consensus from multiple firms suggests confidence in the pipeline, but the Jefferies downgrade tempers enthusiasm.
SMMT Technical Analysis
The stock is in a sustained downtrend, with a 1-year price change of -31.83% and currently trading at 49.8% of its 52-week range (price $15.42 vs. range $12.55-$30.98). This positioning near the lower end of the range suggests bearish sentiment and potential value trap territory, as the stock has failed to recover from its April 2026 highs near $26.38. Short-term momentum shows a 1-month gain of 3.77% and a 3-month loss of -20.43%, indicating a recent bounce but still deep in negative territory. The divergence between the 1-month positive return and the 1-year decline could signal a short-term mean reversion attempt, but the overall trend remains bearish. The 52-week low of $12.55 provides key support, while resistance sits at the 52-week high of $30.98. A break below $12.55 would likely accelerate selling, while a move above $30.98 would signal a trend reversal. Beta is -1.264, meaning the stock moves inversely to the market, which is unusual and suggests idiosyncratic risk rather than systematic exposure.
Beta
-1.26
-1.26x market volatility
Max Drawdown
-55.5%
Largest decline past year
52-Week Range
$13-$31
Price range past year
Annual Return
-50.5%
Cumulative gain past year
| Period | SMMT Return | S&P 500 |
|---|---|---|
| 1m | -4.1% | +0.8% |
| 3m | -38.1% | +3.5% |
| 6m | -17.2% | +7.2% |
| 1y | -50.5% | +16.5% |
| ytd | -22.0% | +8.4% |
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SMMT Fundamental Analysis
Summit Therapeutics has zero revenue, as it is a pre-commercialization biotech firm. The most recent quarterly revenue (Q4 2025) was $0, consistent with prior quarters, and the company relies on licensing and service revenue of $3.973 million (from revenue segments) for minimal top-line. The lack of product revenue means the growth trajectory is binary, dependent on clinical and regulatory milestones. Net income for Q4 2025 was -$219.2 million, a significant loss compared to -$61.2 million in Q4 2024, driven by higher R&D expenses ($147.3 million vs. $51.4 million) and SG&A ($77.7 million vs. $14.4 million). Gross margin is negative (gross profit of -$4,355 on zero revenue), typical for pre-revenue biotechs. The company is unprofitable, with net losses widening over the past year (TTM net income -$1.08 billion vs. -$221 million in prior TTM). The trajectory is away from profitability as spending accelerates. Balance sheet shows a current ratio of 9.87, indicating strong liquidity, and debt-to-equity of 0.032, suggesting minimal leverage. However, free cash flow is deeply negative at -$100.2 million in Q4 2025, and the company relies on equity financing (common stock issued $429.2 million in Q4 2025) to fund operations. ROE is -220.8%, reflecting severe shareholder dilution and losses.
Quarterly Revenue
$0.0B
2025-12
Revenue YoY Growth
N/A
YoY Comparison
Gross Margin
N/A
Latest Quarter
Free Cash Flow
$-323587000.0B
Last 12 Months
Revenue Breakdown
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Valuation Analysis: Is SMMT Overvalued?
Since net income is negative, we use the price-to-sales (PS) ratio. However, with zero revenue, the PS ratio is undefined (0), making it uninformative. Instead, we consider the price-to-book (PB) ratio of 26.74, which is the primary valuation metric. The trailing PE is -12.15 and forward PE is -13.18, both negative due to losses. The PB of 26.74x is extremely high, reflecting the market's valuation of the company's cash and pipeline potential rather than earnings. Compared to the biotechnology industry average PB of roughly 4-6x, Summit trades at a massive premium (over 4x the industry), which is typical for pre-revenue biotechs with promising pipelines but also indicates high expectations. Historically, the PB ratio has ranged from 1.33 (Q3 2022) to 79.89 (Q3 2025), and the current 26.74x is near the middle of that range. This suggests the stock is not at extreme historical valuation levels, but the wide range reflects the binary nature of biotech investing.
PE
-12.1x
Latest Quarter
vs. Historical
N/A
5-Year PE Range 17x~59x
vs. Industry Avg
N/A
Industry PE ~N/A*
EV/EBITDA
-12.0x
Enterprise Value Multiple

