BeOne Medicines Ltd. American Depositary Shares
ONC
$303.96
+1.76%
BeOne Medicines Ltd., formerly BeiGene, is a commercial-stage biotechnology company focused on developing and commercializing oncology therapeutics, with its lead product Brukinsa (zanubrutinib) treating multiple forms of Non-Hodgkin lymphoma and leukemia. The company distinguishes itself as a global player in oncology, competing with AbbVie and AstraZeneca, while maintaining a robust pipeline of over 50 clinical-stage drug candidates targeting various cancers. The current investor narrative centers on the company's transition to profitability, driven by strong Brukinsa sales (74% of revenue) and expanding commercial portfolio, though questions remain about the sustainability of growth amid competitive pressures and the pace of pipeline advancement.…
ONC
BeOne Medicines Ltd. American Depositary Shares
$303.96
ONC 12-Month Price Forecast
Wall Street consensus
The stock is covered by 15 analysts, with a consensus leaning bullish. The average target price is not directly provided, but based on the estimated EPS average of $20.04 and forward P/E of 30.69x, the implied target price is approximately $615 (20.04 * 30.69), representing 106% upside from the current price of $298.70. The consensus recommendation is likely a Buy, given the majority of recent ratings are Buy or Outperform. The high target of $21.27 EPS implies a price of ~$653, while the low target of $19.08 EPS implies ~$586, suggesting a relatively tight range of about 11% around the average. This tight spread indicates strong conviction among analysts. Recent ratings actions include a downgrade from Jefferies (Hold from Buy) in March 2026, but other firms like Truist, Guggenheim, RBC, and Barclays have maintained positive ratings. The wide spread between the current price and analyst targets suggests significant upside potential, but also reflects the high uncertainty around the company's ability to sustain its growth trajectory and profitability.
ONC Technical Analysis
The stock is in a long-term uptrend, with a 1-year price change of +17.88%, but has experienced significant volatility. Currently trading at $298.70, it sits at 77.5% of its 52-week range ($249.00 low to $385.22 high), indicating it is well off the highs but above the lows. This positioning suggests the stock is in a recovery phase after a pullback, but not yet at overbought levels that would signal a peak. The 52-week low of $249.00 provides a key support level, while the high of $385.22 represents major resistance. With a beta of 0.494, the stock is significantly less volatile than the broader market, which may appeal to risk-averse investors but also implies less upside participation in rallies. Short-term momentum shows a divergence: the 1-month change is +13.31%, indicating a strong recent bounce, while the 3-month change is -3.54%, reflecting the prior downtrend. This positive 1-month momentum against a negative 3-month trend suggests a potential short-term reversal or mean reversion, but the 6-month change of -11.60% confirms the intermediate-term downtrend remains intact. The relative strength versus SPY is positive over 1 month (+9.24%) but negative over 3 months (-14.65%), reinforcing the mixed signals. Key support is at the 52-week low of $249.00, a break below which could signal a continuation of the downtrend. Resistance is at the 52-week high of $385.22; a breakout above would indicate a resumption of the long-term uptrend. The stock's low beta of 0.494 means it is about 50% less volatile than the S&P 500, which could limit downside risk but also reduce upside potential in strong market rallies.
Beta
0.49
0.49x market volatility
Max Drawdown
-31.1%
Largest decline past year
52-Week Range
$249-$385
Price range past year
Annual Return
+21.4%
Cumulative gain past year
| Period | ONC Return | S&P 500 |
|---|---|---|
| 1m | +14.9% | +1.0% |
| 3m | -1.9% | +7.9% |
| 6m | -12.3% | +8.5% |
| 1y | +21.4% | +20.1% |
| ytd | -2.3% | +9.9% |
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ONC Fundamental Analysis
Revenue growth is accelerating, with Q4 2025 revenue of $1.498 billion, up 32.84% year-over-year from $1.128 billion in Q4 2024. The multi-quarter trend shows consistent growth: Q1 2025 revenue was $1.117 billion, Q2 $1.315 billion, Q3 $1.412 billion, and Q4 $1.498 billion, indicating a steady upward trajectory. Product revenue of $1.902 billion (from segments) dominates, with collaboration revenue of $39 million, highlighting Brukinsa's central role. The company has achieved profitability, with Q4 2025 net income of $66.5 million, compared to a net loss of $151.9 million in Q4 2024. Gross margin improved to 90.49% in Q4 2025 from 85.76% in Q4 2024, reflecting operating leverage. Operating margin turned positive at 12.35% in Q4 2025, versus -7.04% in Q4 2024, demonstrating significant margin expansion as the company scales. The balance sheet is strong, with a current ratio of 3.41 and low debt-to-equity of 0.25, indicating ample liquidity and conservative leverage. Free cash flow turned positive at $131.3 million in Q4 2025, compared to negative free cash flow in prior quarters, signaling improved cash generation. ROE improved to 6.77% (trailing twelve months), though still modest, reflecting the company's asset-heavy model. The company has $4.61 billion in cash, providing a solid cushion for R&D investment.
Quarterly Revenue
$1.5B
2025-12
Revenue YoY Growth
+32.8%
YoY Comparison
Gross Margin
90.5%
Latest Quarter
Free Cash Flow
$613191000.0B
Last 12 Months
Revenue & Net Income Trends (2 Years)
Revenue Breakdown
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Valuation Analysis: Is ONC Overvalued?
Since net income is positive (TTM net income of $382.5 million), the trailing P/E ratio of 182.85x is the primary valuation metric. The forward P/E of 30.69x implies a dramatic compression, reflecting expectations of significant earnings growth. The gap between trailing and forward P/E suggests the market anticipates a sharp earnings inflection, which is consistent with the recent profitability turnaround. Compared to the biotechnology industry average P/E of approximately 22x (estimated), ONC's trailing P/E of 182.85x represents a 731% premium, while the forward P/E of 30.69x is a 39.5% premium. The premium is partially justified by the company's high revenue growth (32.8% YoY) and improving margins, but the trailing multiple is extreme and implies high expectations. Historically, ONC's trailing P/E has ranged from negative (when unprofitable) to over 200x. The current trailing P/E of 182.85x is near the top of its historical range, suggesting the market is pricing in optimistic future earnings. The forward P/E of 30.69x is more moderate but still above the industry average, indicating that while growth is expected, the stock is not cheap on a forward basis.
PE
182.9x
Latest Quarter
vs. Historical
High-End
5-Year PE Range 3x~205x
vs. Industry Avg
N/A
Industry PE ~N/A*
EV/EBITDA
80.4x
Enterprise Value Multiple

